X-Biotix is focused on the discovery of novel small molecule antibiotics that target resistant Gram-negative bacteria. The scientific foundation for X-Biotix Therapeutics is based on screening novel targets using chemical matter from DNA-encoded screening libraries containing hundreds of billions of molecules. The company employs a unique combination of proprietary biological and genetic tools, library screening, and its deep knowledge of antibacterial medicinal chemistry to discover and advance novel tractable chemical matter into optimized antibacterial molecules that show selective activity against all or specific gram-negative ESKAPE pathogens and which can be further developed into drug candidates. Priority is given to the screening of multiple targets that have the potential to be inhibited by one compound (dual target inhibition). So far, this approach has led to a pipeline of first-in-class programs directed against a range of Gram-negative targets with different mechanisms of action.